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Brain Defenders: Harness the Power of Your Immune Cells to Protect Your Brain for Life

From #1 New York Times bestselling author Dr. David Perlmutter comes a groundbreaking guide to the brain's immune cells--essential to preventing disease and sustaining peak cognitive function and mental health

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Hardcover

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$32.00

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Pair It With Feed My Mind
  • The Sip: Classic dark cocoa
  • The Cookie: Oatmeal Cranberry-Walnut Cookie
  • The Cozy: Desk throw, notebook, tabs and a good reading light
We've been fighting the wrong enemy. For decades, medicine has pointed its weapons at symptoms like memory loss, tremors, headaches, and lethargy, while ignoring the root causes of diseases like Alzheimer's, Parkinson's, and major depression. In Brain Defenders, neurologist Dr. David Perlmutter flips the script, exposing the real culprits: malfunctioning microglia, tiny immune cells that, when metabolically hijacked, go rogue and attack the very neurons they're meant to protect.
With clarity and urgency, Dr. Perlmutter explains how a silent battle rages in the brain. Microglia can become either warriors of protection or agents of destruction--and the outcome depends largely on how we live. In Brain Defenders, you will: 
  • Learn the science of immunometabolism and the relationship between energy and your cells
  • Understand the overlooked role of inflammation in everything from dementia to long COVID--and why the immune system may be the brain's greatest threat and hope
  • Discover how your lifestyle affects the fate of your microglia and, in turn, your cognitive future
  • Uncover the surprising link between metabolic health and brain resilience, and how tools like fasting, sleep, and even oxygen therapy can restore damaged neural networks
  • Explore therapeutic interventions--from metformin to lion's mane mushroom--that support healing and slow neural decline
Neurodegeneration, cognitive impairment, and mood disorders are not inevitable, but often the result of chronic, controllable inflammation. Drawing on the latest peer-reviewed science and grounded in decades of neurological care, Dr. Perlmutter delivers a powerful message: the future of your brain health is in your hands.
DP
David Perlmutter

David Perlmutter, MD, is an American neurologist, bestselling author, and health educator known for exploring the connections between nutrition, brain health, inflammation, and overall wellness. His work focuses on how lifestyle choices, including diet, sleep, and physical activity, may influence cognitive function and long-term health.

Perlmutter is the author of several popular health and wellness books, including *Grain Brain*, *Brain Maker*, *Brain Wash*, coauthored with his son Austin Perlmutter, MD, and *Drop Acid*. His writing examines topics such as the gut-brain connection, the microbiome, metabolic health, and the relationship between everyday habits and neurological well-being. While some of his dietary recommendations remain debated within the medical community, his books have helped bring conversations about nutrition and brain health to a broad readership.

For readers curious about how the brain and body work together, Perlmutter offers an accessible introduction to complex health topics. His books are especially suited to readers interested in neuroscience, nutrition, the gut-brain connection, healthy aging, and exploring how lifestyle habits may affect physical and cognitive well-being.

See all book by David Perlmutter

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